Optical coherence tomography imaging of structural components of the respiratory tract

Suzanne C. Whiteman; Ying Yang; D. Gey van Pittius; Yonghong He; M. A. Spiteri; Ruikang K. Wang

doi:10.1117/12.572000

29 July 2004 Optical coherence tomography imaging of structural components of the respiratory tract

Suzanne C. Whiteman, Ying Yang, D. Gey van Pittius, Yonghong He, M. A. Spiteri, Ruikang K. Wang

Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572000
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

For optimal curative treatment and the prevention of metastasis, it is critical that premalignant lesions are detected as early as possible. However, current diagnostic methods for human airways do not possess sufficient resolution and tissue penetration depth to detect these aberrations. Therefore it is necessary to develop safe, reproducible imaging techniques with high spatial resolution. In this study, optical coherence tomography (OCT) was used to obtain cross sectional images of porcine respiratory tract tissue. OCT images were compared to parallel conventional histological sections. Our objective was to establish whether OCT differentiates the microstructural layers of the respiratory tract. These data demonstrate that OCT can characterize the multilayered structure of the airways, with a depth of up to 2 mm and a 10 μm spatial resolution. The subtle structural differences between trachea, main bronchus and tertiary bronchus were clearly identifiable. The epithelium, sub-epithelial tissues and cartilage were individually defined. In addition, the relative thickness of the structural components was comparable to histological sections. These data suggest that OCT is a highly feasible diagnostic tool, which requires further exploration for early detection of human airway pathology.

Citation Download Citation

Suzanne C. Whiteman, Ying Yang, D. Gey van Pittius, Yonghong He, M. A. Spiteri, and Ruikang K. Wang "Optical coherence tomography imaging of structural components of the respiratory tract", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572000

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KEYWORDS

Optical coherence tomography

Tissues

Cartilage

Tissue optics

Coherence imaging

Spatial resolution

Diagnostics

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