Technical feasibility evaluation of fluorescence signal detection by compact photonic explorer for better health

Gang Zhang; LeMing Wang; Q. Z. Wang; J.-C. Luo; Fanan Zeng; Manuel Zevallos; Yury Budansky; Scott Alfano; Alvin Katz; R. R. Alfano

doi:10.1117/12.559963

22 October 2004 Technical feasibility evaluation of fluorescence signal detection by compact photonic explorer for better health

Gang Zhang, LeMing Wang, Q. Z. Wang, J.-C. Luo, Fanan Zeng, Manuel Zevallos, Yury Budansky, Scott Alfano, Alvin Katz, R. R. Alfano

Author Affiliations +

Proceedings Volume 5524, Novel Optical Systems Design and Optimization VII; (2004) https://doi.org/10.1117/12.559963
Event: Optical Science and Technology, the SPIE 49th Annual Meeting, 2004, Denver, Colorado, United States

Abstract

The lowest detectable fluorescence signal level from biomedical specimens have been determined using a spectrometer, cooled CCD detector, and PIN photodiode with 365 nm UV LED light excitation. The data indicates the PIN photodiodes have adequate sensitivity for detection of tissue fluorescence with a sufficient signal-to-noise ratio. This data is being used to design a "pill-sized" Compact Photonics Explorer (CPE) for in vivo cancer optical diagnostics.

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Gang Zhang, LeMing Wang, Q. Z. Wang, J.-C. Luo, Fanan Zeng, Manuel Zevallos, Yury Budansky, Scott Alfano, Alvin Katz, and R. R. Alfano "Technical feasibility evaluation of fluorescence signal detection by compact photonic explorer for better health", Proc. SPIE 5524, Novel Optical Systems Design and Optimization VII, (22 October 2004); https://doi.org/10.1117/12.559963

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