Penetration depth of diffused photons re-emitted from layered tissue and its application to near-infrared spectroscopy

Yunhan Luo; Houxin Cui; Yonghui Han; Wenliang Chen; Kexin Xu

doi:10.1117/12.576250

18 January 2005 Penetration depth of diffused photons re-emitted from layered tissue and its application to near-infrared spectroscopy

Yunhan Luo, Houxin Cui, Yonghui Han, Wenliang Chen, Kexin Xu

Author Affiliations +

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.576250
Event: Photonics Asia, 2004, Beijing, China

Abstract

Concept of penetration depth of diffused photons migrating in turbid medium is introduced, and subsequently, distribution of penetration depth and mean penetration depth in three-layered media are investigated by using of Monte Carlo simulation technique. An optimal source-detector separation is derived from the mean penetration depth referring to monitoring the change of chromophore concentration of the sandwiched layer. In order to verify the separation, we perform Monte Carlo simulations 80 times with varied absorption coefficient of the sandwiched layer. All these diffuse reflectance of 80 times of Monte Carlo simulations are used to construct a calibration model with the method of PLS. High correlation coefficients and low RMSEP at the optimal separation have conformed correctness of the selection.

Citation Download Citation

Yunhan Luo, Houxin Cui, Yonghui Han, Wenliang Chen, and Kexin Xu "Penetration depth of diffused photons re-emitted from layered tissue and its application to near-infrared spectroscopy", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.576250

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