Percutaneous MRI-guided laser thermal therapy in canine prostate

Roger J. McNichols; Ashok Gowda; Marc D. Gelnett; Roger J. Stafford

doi:10.1117/12.587747

25 April 2005 Percutaneous MRI-guided laser thermal therapy in canine prostate

Roger J. McNichols, Ashok Gowda, Marc D. Gelnett, Roger J. Stafford

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.587747
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Prostate cancer is the most common cancer in American men excluding skin cancer, and approximately 230,000 cases of prostate cancer will be diagnosed in the U.S. in 2004. In the non-surgical treatment of localized prostate cancer, fiberoptically delivered interstitial laser thermal therapy may be ideal for treating discrete tumors with minimal invasiveness. Real-time magnetic resonance imaging can be used to compute temperature changes based on the proton resonance frequency (PRF) shift, and two-dimensional maps of temperature rise and chronic thermal damage can be constructed in order to control laser therapy. In this work, we describe an MRI-compatible percutaneous grid template and localization and planning software for precise placement of minimally invasive laser catheters to effect a target ablation zone. We evaluated the accuracy of the catheter placement, and we present our preliminary experience with percutaneous MRI-guided feedback controlled laser ablation in a canine prostate model. Histological analysis is used to assess the effectiveness and accuracy of treatment visualization.

Citation Download Citation

Roger J. McNichols, Ashok Gowda, Marc D. Gelnett, and Roger J. Stafford "Percutaneous MRI-guided laser thermal therapy in canine prostate", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.587747

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