Dual modality fluorescence and reflectance hyperspectral imaging: principle and applications

Matthew E. Martin; Musundi B. Wabuyele; Masoud Panjehpour; Mary N. Phan; Bergein F. Overholt M.D.; Robert C. DeNovo D.V.M.; Tamberlyn Moyers; Seong Gon Song; Tuan Vo-Dinh

doi:10.1117/12.604445

1 April 2005 Dual modality fluorescence and reflectance hyperspectral imaging: principle and applications

Matthew E. Martin, Musundi B. Wabuyele, Masoud Panjehpour, Mary N. Phan, Bergein F. Overholt M.D., Robert C. DeNovo D.V.M., Tamberlyn Moyers, Seong Gon Song, Tuan Vo-Dinh

Author Affiliations +

Proceedings Volume 5692, Advanced Biomedical and Clinical Diagnostic Systems III; (2005) https://doi.org/10.1117/12.604445
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We present the principles and applications of our dual-modality fluorescence and reflectance hyperspectral imaging (DMHSI) system. In this paper we report on background work done using laser induced fluorescence (LIF) by the group in the early detection of esophageal cancer. We then demonstrate the capabilities of our new DMHSI system. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Preliminary results, performed on mouse tissue, show that the system can delineate normal and malignant tissue regions in real-time.

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Matthew E. Martin, Musundi B. Wabuyele, Masoud Panjehpour, Mary N. Phan, Bergein F. Overholt M.D., Robert C. DeNovo D.V.M., Tamberlyn Moyers, Seong Gon Song, and Tuan Vo-Dinh "Dual modality fluorescence and reflectance hyperspectral imaging: principle and applications", Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); https://doi.org/10.1117/12.604445

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