Estimation of contribution of multiple scattering into the optical coherence tomography signal from layers of different biological tissues

Marina S. Fedosseeva; Mikhail Yu. Kirillin; Alexander V. Priezzhev; Risto Myllyla

doi:10.1117/12.634665

22 June 2005 Estimation of contribution of multiple scattering into the optical coherence tomography signal from layers of different biological tissues

Marina S. Fedosseeva, Mikhail Yu. Kirillin, Alexander V. Priezzhev, Risto Myllyla

Author Affiliations +

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634665
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

Optical coherence tomography (OCT) signals from blood layers (thickness of 0.5 mm) for the haematocrits of 35, 10 and 5%, intralipid (thickness of 2 mm) for 10, 5 and 2% concentrations, as well as from upper skin layers (stratum corneum and epidermis) for the thicknesses of 120, 135 and 150 jim were simulated using Monte-Carlo method. For blood and intralipid simulations the wavelength was chosen equal to 820 nm and for upper skin layers simulation equal to 630 nm. The coherence length was assumed to be 15 Iim. The contribution of multiple scattering to OCT was analyzed for the models under study. It was shown that for blood the percentage ofmultiple scattering contribution in to the signal increases as haematocrit goes up: for 5%-haematocrit the contribution is less than 1%, for 10%-haematocrit about 4.5%, and for 35% - some 64%. It appears that for intralipid the major contribution to the signal for all the concentrations under consideration is made by multiple scattering: for 2%-concentration - about 44.5%, for 5%-concentration -72%, and for 10%-concentration - more than 85%. Apparently, for skin surface layers the multiple scattering contribution rises as the layer thickness increases: as the layer thickness is varied from 20 to 50 im the multiple scattering contribution varies from 14 to 74%.

Citation Download Citation

Marina S. Fedosseeva, Mikhail Yu. Kirillin, Alexander V. Priezzhev, and Risto Myllyla "Estimation of contribution of multiple scattering into the optical coherence tomography signal from layers of different biological tissues", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634665

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