Induction and detection of immune responses by photoimmunotherapy

Wei R. Chen; Kenneth E. Bartels D.V.M.; Hong Liu; Robert E. Nordquist

doi:10.1117/12.634654

22 June 2005 Induction and detection of immune responses by photoimmunotherapy

Wei R. Chen, Kenneth E. Bartels D.V.M., Hong Liu, Robert E. Nordquist

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634654
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

A specific method of photoimmunotherapy, using a combination of selective photothermal laser tissue interactions and an in situ immunoadjuvant, has showed promising results in pre-clinical studies. Its effect on untreated remote metastases is especially interesting. To understand the mechanism of the combination of laser therapy and immunotherapy, immune responses have been investigated. The following laser photoimmunotherapy-induced tumor-specific immunological activities have been observed in our studies. 1. The photoimmunotherapy-cured tumor-bearing animal could resist repeated, dose escalated tumor rechallenges. 2. The serum from cured animals showed tumor-specific antibodies to enhance the binding to the tumor cells. 3. The serum from cured animals could also serve as antibody sources to bind certain specific tumor proteins. 4. In vivo, the spleen cells from cured animals showed anti-tumor immunity that could be adoptively transferred. The methods and the results of these immune responses are summarized.

Citation Download Citation

Wei R. Chen, Kenneth E. Bartels D.V.M., Hong Liu, and Robert E. Nordquist "Induction and detection of immune responses by photoimmunotherapy", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634654

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