Applications of surface-enhanced Raman spectroscopy (SERS) for biosensing: an analysis of reproducible commercially available substrates

Troy A. Alexander

doi:10.1117/12.630659

10 November 2005 Applications of surface-enhanced Raman spectroscopy (SERS) for biosensing: an analysis of reproducible commercially available substrates

Troy A. Alexander

Author Affiliations +

Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 600703 (2005) https://doi.org/10.1117/12.630659
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

The rapid and accurate determination of bacterial spores in sterile environments (i.e., food preparation areas and hospitals) is of great importance in the minimization of bacteria-driven illnesses. Surface- Enhanced-Raman-Scattering (SERS) is potentially a very sensitive spectroscopic technique for the detection of biological threat agents. SERS can be made a more robust and attractive spectroscopic technique for biological threat agent sensing by developing high sensitivity, high reproducibility SERS-active substrates. The maturation of Si-based semiconductor fabrication techniques has facilitated the development and marketing of highly reproducible and sensitive SERS-active substrates. Klarite^TM SERS-active substrates (Mesophotonics LTD) have been analyzed for utility in the potential identification of biological threat agents. Concurrently, we have investigated prototype SERS- active substrates under development by Nanospectra Biosciences, Inc. Substrate spatial reproducibility and substrate-to-substrate reproducibility will be discussed.

Citation Download Citation

Troy A. Alexander "Applications of surface-enhanced Raman spectroscopy (SERS) for biosensing: an analysis of reproducible commercially available substrates", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 600703 (10 November 2005); https://doi.org/10.1117/12.630659

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available