Digital holographic optical coherence imaging of tumor tissue

Kwan Jeong; John J. Turek; David D. Nolte

doi:10.1117/12.646686

20 February 2006 Digital holographic optical coherence imaging of tumor tissue

Kwan Jeong, John J. Turek, David D. Nolte

Proceedings Volume 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X; 60791G (2006) https://doi.org/10.1117/12.646686
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Holographic Optical Coherence Imaging (OCI) uses spatial heterodyne detection in direct analogy with the temporal heterodyne detection of time-domain OCT. The spatial demodulator can be a sensitive dynamic holographic film or can be a CCD array placed directly at the hologram plane. We show that a digital hologram captured at the Fourier plane requires only a simple 2D inverse FFT of the digital hologram to compute the real image and its conjugate. Our recording on the optical Fourier plane has an advantage for diffuse targets because the intensity distribution of diffuse targets is relatively uniform at the Fourier plane and hence uses the full dynamic range of CCD camera. We applied this technique to human liver tumor spheroids and produced depth-resolved images to depth of 1.4 mm.

Citation Download Citation

Kwan Jeong, John J. Turek, and David D. Nolte "Digital holographic optical coherence imaging of tumor tissue", Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 60791G (20 February 2006); https://doi.org/10.1117/12.646686

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available