Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

Hao F. Zhang; Meng-Lin Li; Konstantin Maslov; George Stoica; Lihong V. Wang

doi:10.1117/12.645138

6 March 2006 Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

Hao F. Zhang, Meng-Lin Li, Konstantin Maslov, George Stoica, Lihong V. Wang

Proceedings Volume 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 60861E (2006) https://doi.org/10.1117/12.645138
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized in vivo using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 μm and an axial resolution of 15 μm. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.

Citation Download Citation

Hao F. Zhang, Meng-Lin Li, Konstantin Maslov, George Stoica, and Lihong V. Wang "Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60861E (6 March 2006); https://doi.org/10.1117/12.645138

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