Iterative indirect methods for determination of optical parameters of biological tissues

Maxim S. Zarembo; Nickolai N. Golovin; Yuri P. Meshalkin

doi:10.1117/12.697319

21 July 2006 Iterative indirect methods for determination of optical parameters of biological tissues

Maxim S. Zarembo, Nickolai N. Golovin, Yuri P. Meshalkin

Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 616315 (2006) https://doi.org/10.1117/12.697319
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

In this work the version of indirect iterative methods for determination of optical parameters of biological tissues is presented. This method determines such optical parameters as anisotropy factor (g), absorption coefficient (μ_a), scattering coefficient (μ_s). Both these parameters determine mean free path (d_s) which use in simulation of light propagating trough biological tissue. For light propagation modeling we used weight time-resolved Monte Carlo method (MCM), time-depended diffusion approximation method (DA), and hybrid method (MCM-DA). Three these methods can use in different cases. The DA is less accurate and universal technique than MCM but it, in contrast to MCM, doesn't need large computational burden. Hybrid model has advantages of both methods. We found dependences of transmitted through biotissue pulse spreading with which optical parameters are determined. In this study we didn't take into account femtosecond pulse spreading at the expense of refractive index dispersion.

Citation Download Citation

Maxim S. Zarembo, Nickolai N. Golovin, and Yuri P. Meshalkin "Iterative indirect methods for determination of optical parameters of biological tissues", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616315 (21 July 2006); https://doi.org/10.1117/12.697319

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