A linear GPST-based scheme for time-domain fluorescence molecular tomography

Feng Gao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada

doi:10.1117/12.694199

13 February 2007 A linear GPST-based scheme for time-domain fluorescence molecular tomography

Feng Gao, Huijuan Zhao, Yukari Tanikawa, Yukio Yamada

Proceedings Volume 6434, Optical Tomography and Spectroscopy of Tissue VII; 64342F (2007) https://doi.org/10.1117/12.694199
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Fluorescence diffuse optical tomography (DOT) has attracted many attentions from the community of biomedical imaging, since it provides effective enhancement in imaging contrast. This modality is now rapidly evolving as a potential means of monitoring molecular events in small living organisms with help of molecule-specific contrast agents, referred to as fluorescence molecular tomography (FMT). FMT could greatly promote pathogenesis research, drug development, and therapeutic intervention. Although FMT in steady-state and frequency-domain modes have been promisingly demonstrated, the extension to time-domain scheme is imminent for its several unique advantages over the others. By extending the previously developed generalized pulse spectrum technique (GPST) for time-domain DOT, we propose a linear, featured-data image reconstruction algorithm for time-domain FMT that can simultaneously reconstruct both fluorescent yield and lifetime images, and validate the methodology with simulated data.

Citation Download Citation

Feng Gao, Huijuan Zhao, Yukari Tanikawa, and Yukio Yamada "A linear GPST-based scheme for time-domain fluorescence molecular tomography", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64342F (13 February 2007); https://doi.org/10.1117/12.694199

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