White-light oblique-incidence diffuse reflectance spectroscopy for classification of in-vivo pigmented skin lesions

Alejandro Garcia-Uribe; Elizabeth B. Smith; Madeleine Duvic M.D.; Lihong V. Wang

doi:10.1117/12.699633

21 February 2007 White-light oblique-incidence diffuse reflectance spectroscopy for classification of in-vivo pigmented skin lesions

Alejandro Garcia-Uribe, Elizabeth B. Smith, Madeleine Duvic M.D., Lihong V. Wang

Author Affiliations +

Proceedings Volume 6435, Optical Interactions with Tissue and Cells XVIII; 64350L (2007) https://doi.org/10.1117/12.699633
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

A study of in-vivo classification of pigmented skin lesions using oblique-incidence diffuse reflectance spectroscopy is presented. Spatio-spectral data in the wavelength range from 455 to 765 nm are collected from 111 pigmented lesions including 10 histopathologically diagnosed as melanoma. The first 67 lesions are used for training the classifiers, and 44 lesions are used for testing. The first classifier separates (1) malignant melanoma and severe dysplastic nevi from (2) moderate and mild dysplastic nevi, common nevi, actinic and seborrheic keratoses. The second classifier next distinguishes between (a) moderate and mild dysplastic nevi, common nevi from (b) actinic and seborrheic keratoses. The third classifier further separates (I) moderate and mild dysplastic nevi from (II) common nevi. The first classifier performs with 100% sensitivity and 91% specificity with overall classification rates of 93% and 95 % for the training and testing sets, respectively. The second classifier has classification rates of 95% and 97 % for the training and testing sets, respectively, whereas the third classifier has classification rates of 98% and 94 % for the training and testing sets, respectively.

Citation Download Citation

Alejandro Garcia-Uribe, Elizabeth B. Smith, Madeleine Duvic M.D., and Lihong V. Wang "White-light oblique-incidence diffuse reflectance spectroscopy for classification of in-vivo pigmented skin lesions", Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350L (21 February 2007); https://doi.org/10.1117/12.699633

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