Nanomaterials, such as semiconductor Quantum Dots (QD) and Iron Oxide nanocrystals possess unique properties that
are not available in their bulk phase. Some of these properties include the narrow emission spectra, superior brightness
and higher photostability of QDs, and the superparamagnetic properties of Iron Oxide nanocrystals. In the past decade,
these two nanomaterials have separately seen widespread use in a variety of biomedical applications ranging from
multiplexed biomolecular detection to isolation and magnetic manipulation of disease cells and molecules respectively.
Here, we describe a method for combining QDs and Iron Oxide nanocrystals into a micron-sized host material in a rapid
fashion. The resulting beads are dual functional, i.e. they are optically encoded, and can be manipulated with a
permanent magnet. The beads have great potential in biomedical applications because of the combined ability to enrich
and detect multiple target molecules from heterogeneous and diluted biological samples. The development of multifunctional
composite materials by combining novel nanomaterials is bound to open avenues for ultrasensitive and
quantitative bioassays.
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