Determination of optical properties in tissue: modeling and simulation

Zheng Ma; Dongli Qin; Feng Gao

doi:10.1117/12.741568

1 May 2007 Determination of optical properties in tissue: modeling and simulation

Zheng Ma, Dongli Qin, Feng Gao

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65340S (2007) https://doi.org/10.1117/12.741568
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

In this paper, a Monte Carlo (MC) based model of diffuse reflectance is introduced to retrieval the light absorption and scattering coefficients of multi-layered tissue. The absorption and transport scattering coefficients of biological tissues determine the radial dependence of the diffuse reflectance that is due to a point source. The MC model of diffuse reflectance consists of a forward part and an inverse one. The forward refers to a multi-layered MC simulation at a certain source detector separation, which results a time-resolved profile. The inverse one is a fitting procedure based on Levenberg-Marquardt algorithm using forward model in iteration, and the normalized intensity in each time bin is fitted. Tests with independent MC simulations show the errors in the deduced absorption and reduced scattering coefficients. Although a high amount of computation time is needed, compared with investigation methods using diffuse approximation to the transport equation, this model is valid for a wider range of optical properties and is easily adaptable to exiting probe geometries.

Citation Download Citation

Zheng Ma, Dongli Qin, and Feng Gao "Determination of optical properties in tissue: modeling and simulation", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65340S (1 May 2007); https://doi.org/10.1117/12.741568

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