Blood flow structure in patients with coronary heart disease

Lidia I. Malinova; Georgy V. Simonenko; Tatyana P. Denisova; Valery V. Tuchin

doi:10.1117/12.741011

26 April 2007 Blood flow structure in patients with coronary heart disease

Lidia I. Malinova, Georgy V. Simonenko, Tatyana P. Denisova, Valery V. Tuchin

Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 65351V (2007) https://doi.org/10.1117/12.741011
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

Blood flow structure was studied by PC integrated video camera with following slide by slide analysis. Volumetric blood flow velocity was supporting on constant level (1 ml/h). Silicone tube of diameter comparable with coronary arteries diameter was used as vessel model. Cell-cell interactions were studied under glucose and anticoagulants influence. Increased adhesiveness of blood cells to tube walls was revealed in patient with coronary heart disease (CHD) compare to practically healthy persons (PHP). In patients with stable angina pectoris of high functional class and patients with AMI shear stress resistant erythrocyte aggregates were predominating in blood flow structure up to microclots formation. Clotting and erythrocytes aggregation increase as response to glucose solution injection, sharply defined in patients with CHD. Heparin injection (10 000 ED) increased linear blood flow velocity both in patients with CHD and PHP. After compare our results with other author's data we can consider that method used in our study is sensible enough to investigate blood flow structure violations in patients with CHD and PHP. Several differences of cell-cell interaction in flow under glucose and anticoagulant influence were found out in patients with CHD and PHP.

Citation Download Citation

Lidia I. Malinova, Georgy V. Simonenko, Tatyana P. Denisova, and Valery V. Tuchin "Blood flow structure in patients with coronary heart disease", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351V (26 April 2007); https://doi.org/10.1117/12.741011

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