Dynamic imaging of penetration and decontamination after chemical eye burn using optical coherence tomography

Felix Spöler; Michael Först; Heinrich Kurz; Markus Frentz; Norbert F. Schrage

doi:10.1117/12.727820

11 July 2007 Dynamic imaging of penetration and decontamination after chemical eye burn using optical coherence tomography

Felix Spöler, Michael Först, Heinrich Kurz, Markus Frentz, Norbert F. Schrage

Author Affiliations +

Proceedings Volume 6627, Optical Coherence Tomography and Coherence Techniques III; 66270B (2007) https://doi.org/10.1117/12.727820
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

For chemical burns a considerable lack of methods exists for defining penetration kinetics and effects of decontamination within biological structures. We demonstrate that time-resolved high-resolution optical coherence tomography can close this gap by monitoring changes in scattering properties and thicknesses of rabbit cornea ex vivo after topical application of different corrosives. Modifications in the corneal microstructure due to direct chemical interaction or changes in the hydration state as a result of osmotic imbalance compromise the corneal transparency. The associated increase in light scattering intensity within the cornea is observed with high spatial and temporal resolution. Parameters affecting the severity of pathophysiological damage like diffusion velocity, depth of penetration, resistance of barriers, and effectiveness of emergency treatment procedures are obtained. This study demonstrates the potential of high-resolution OCT for the visualization and direct non-invasive measurement of specific interaction of chemicals with the eye, exemplified on hydrofluoric acid burn.

Citation Download Citation

Felix Spöler, Michael Först, Heinrich Kurz, Markus Frentz, and Norbert F. Schrage "Dynamic imaging of penetration and decontamination after chemical eye burn using optical coherence tomography", Proc. SPIE 6627, Optical Coherence Tomography and Coherence Techniques III, 66270B (11 July 2007); https://doi.org/10.1117/12.727820

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Cornea

Optical coherence tomography

Eye

Scattering

Tissues

Calcium

Diffusion

Show All Keywords

Keywords/Phrases

Search In:

Publication Years