Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models

Robert H. Wilson; Karthik Vishwanath; Mary-Ann Mycek

doi:10.1117/12.729431

19 July 2007 Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models

Robert H. Wilson, Karthik Vishwanath, Mary-Ann Mycek

Proceedings Volume 6628, Diagnostic Optical Spectroscopy in Biomedicine IV; 66280W (2007) https://doi.org/10.1117/12.729431
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Photon transport in complex biological tissues is most accurately predicted via Monte Carlo (MC) modeling methods, which often require lengthy computation times. In this report, a semi-analytical technique (henceforth referred to as PI-scaling) was derived that combines MC simulation, absorption scaling, and path integrals (PI) to rapidly reconstruct time-resolved reflectance from the surface of bilayered epithelial tissue models. Comparisons to forward MC simulations indicated that the PI−scaling method was accurate to better than 10% for tissue models where the optical properties of the top layer did not greatly influence the time-resolved reflectance. Employing such a method should provide a novel solution to the first step of the problem of rapid simulation of time-resolved reflectance of photons in layered tissues.

Citation Download Citation

Robert H. Wilson, Karthik Vishwanath, and Mary-Ann Mycek "Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66280W (19 July 2007); https://doi.org/10.1117/12.729431

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