High throughput high content live cell screening platform

Rainer Uhl; Rainer Daum; Hartmann Harz; Christian Seebacher; Schomiron Neogy

doi:10.1117/12.729545

13 July 2007 High throughput high content live cell screening platform

Rainer Uhl, Rainer Daum, Hartmann Harz, Christian Seebacher, Schomiron Neogy

Proceedings Volume 6633, Biophotonics 2007: Optics in Life Science; 66330C (2007) https://doi.org/10.1117/12.729545
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

The goal was to develop a light-microscope platform concept, which allows characterization of live cells in microtiter plates or in live-cell slide chambers with a speed, sensitivity and versatility unattainable so far. The goal was achieved by combining several novel technological concepts: a model-based digital control for a voice coil focus drive; scanner technology to follow a continuously moving sample during image acquisition, thus avoiding the usual stop-and-go; fast sectioning capabilities by using slit-scan confocal concepts; motorized dual emission image registration; and integrated environmental control.

Citation Download Citation

Rainer Uhl, Rainer Daum, Hartmann Harz, Christian Seebacher, and Schomiron Neogy "High throughput high content live cell screening platform", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66330C (13 July 2007); https://doi.org/10.1117/12.729545

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