Near-infrared laser photothermal therapy and photodynamic inactivation of cells by using gold nanoparticles and dyes

George G. Akchurin; Garif G. Akchurin; Vladimir A. Bogatyrev; Irina L. Maksimova; George A. Seliverstov; George S. Terentyuk; Boris N. Khlebtsov; Nikolai G. Khlebtsov; Valery V. Tuchin

doi:10.1117/12.733140

11 September 2007 Near-infrared laser photothermal therapy and photodynamic inactivation of cells by using gold nanoparticles and dyes

George G. Akchurin, Garif G. Akchurin, Vladimir A. Bogatyrev, Irina L. Maksimova, George A. Seliverstov, George S. Terentyuk, Boris N. Khlebtsov, Nikolai G. Khlebtsov, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 6645, Nanoengineering: Fabrication, Properties, Optics, and Devices IV; 66451U (2007) https://doi.org/10.1117/12.733140
Event: NanoScience + Engineering, 2007, San Diego, California, United States

Abstract

Light-induced inactivation of dynamic response of somatic frog nerve on electrical pulsed excitation was study ex vivo. The light-sensitive Indocianin Green has been used on photodynamic induced inactivation of the processes generation nerve pulses. Inactivation of consequence action potential of somatic frog nerve using excitation of electrical pulsed was achieved by irradiation with diode laser light in a IR spectral region (λ=810 nm, P~1W/cm²) in the case of Indocianin green. It was discovered that Indocianine green decrease of the amplitude compound action potential of the ensemble neurons. Experiments show effective destruction of cancer cells of ear, mouth and skin by local injection of plasmon resonant gold nanoshells and semiconductor laser (810 nm) irradiation. For destruction such tumors pulse duration was not less than 1microsecond and pulse separation 10 at average power density 1-3 W/sm² and energy density 100-200 J/sm²

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George G. Akchurin, Garif G. Akchurin, Vladimir A. Bogatyrev, Irina L. Maksimova, George A. Seliverstov, George S. Terentyuk, Boris N. Khlebtsov, Nikolai G. Khlebtsov, and Valery V. Tuchin "Near-infrared laser photothermal therapy and photodynamic inactivation of cells by using gold nanoparticles and dyes", Proc. SPIE 6645, Nanoengineering: Fabrication, Properties, Optics, and Devices IV, 66451U (11 September 2007); https://doi.org/10.1117/12.733140

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