Amperometric immunosensor using electric field to improve the interaction between antibody and antigen

Jizhou Sun; Chao Bian; Shanhong Xia

doi:10.1117/12.775039

8 January 2008 Amperometric immunosensor using electric field to improve the interaction between antibody and antigen

Jizhou Sun, Chao Bian, Shanhong Xia

Proceedings Volume 6836, MEMS/MOEMS Technologies and Applications III; 68360C (2008) https://doi.org/10.1117/12.775039
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

This paper proposes a method that using an electric field to improve the immobilization of analyte in an amperometric immunosensor. The amperometric immunosensor, which has a two-microelectrode system enclosed in a SU-8 reaction microwell, has been developed with MEMS technology for the detection of the human immunoglobulin (HIgG). Electric field has been applied above the working electrode by setting the appropriate potential between two electrodes to enable more antigen "IgG" to be assembled to the sensing interface with less time. The results demonstrate that the immunochemical incubation time spent on the immobilization of HIgG has been shortened, and the property of the immunosensor has been enhanced.

Citation Download Citation

Jizhou Sun, Chao Bian, and Shanhong Xia "Amperometric immunosensor using electric field to improve the interaction between antibody and antigen", Proc. SPIE 6836, MEMS/MOEMS Technologies and Applications III, 68360C (8 January 2008); https://doi.org/10.1117/12.775039

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