Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography

Wen-Chuan Kuo; Ming-Wei Hsiung; Jeou-Jong Shyu; Nai-Kuan Chou; Po-Nien Yang

doi:10.1117/12.762170

8 February 2008 Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography

Wen-Chuan Kuo, Ming-Wei Hsiung, Jeou-Jong Shyu, Nai-Kuan Chou, Po-Nien Yang

Author Affiliations +

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 684223 (2008) https://doi.org/10.1117/12.762170
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

In this research, we have used an algorithm to extract four different optical parameters, including the scattering coefficient (μ_s), effective anisotropy factor (g_off), birefringence coefficient (Δn), and fast-axis angle (β) from polarization-sensitive optical coherence tomography (PS-OCT) images. The proposed method was evaluated from a set of phantoms and it yielded valid results. We demonstrate that the optical characteristic of normal and different kinds of atherosclerotic lesions in human vessel can be quantitatively described. Whether change in these quantified optical properties could be used to discriminate between different types of human atherosclerotic plaques was examined.

Citation Download Citation

Wen-Chuan Kuo, Ming-Wei Hsiung, Jeou-Jong Shyu, Nai-Kuan Chou, and Po-Nien Yang "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684223 (8 February 2008); https://doi.org/10.1117/12.762170

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