Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography

Mohamad G. Ghosn; Esteban Carbajal; Natasha Befrui; Valery V. Tuchin; Kirill V. Larin

doi:10.1117/12.762161

5 March 2008 Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography

Mohamad G. Ghosn, Esteban Carbajal, Natasha Befrui, Valery V. Tuchin, Kirill V. Larin

Author Affiliations +

Proceedings Volume 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII; 68471E (2008) https://doi.org/10.1117/12.762161
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

High in-depth resolution imaging, such as Optical Coherence Tomography, could be the next frontier in noninvasive quantification of diffusion in epithelial tissues. In this study we employed OCT in a method that could help differentiate various forms of atherosclerosis and distinguish between normal and diseased tissue. The diffusion of glucose solution in normal and diseased pig aorta in vitro was monitored and the permeability coefficient was calculated. The results suggest that this OCT method may have high potential for early detection of tissue abnormalities while used in diffusion studies.

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Mohamad G. Ghosn, Esteban Carbajal, Natasha Befrui, Valery V. Tuchin, and Kirill V. Larin "Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography", Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 68471E (5 March 2008); https://doi.org/10.1117/12.762161

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KEYWORDS

Tissues

Glucose

Optical coherence tomography

Diffusion

In vitro testing

Tissue optics

Arteries

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