An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique

Huiyuan He; Limin Zhang; Feng Gao; Zheng Ma; Huijian Zhao; Jingying Jiang

doi:10.1117/12.756377

12 February 2008 An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique

Huiyuan He, Limin Zhang, Feng Gao, Zheng Ma, Huijian Zhao, Jingying Jiang

Author Affiliations +

Proceedings Volume 6850, Multimodal Biomedical Imaging III; 68500M (2008) https://doi.org/10.1117/12.756377
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

An image reconstruction scheme for time-domain fluorescence diffuse optical tomography is proposed using a reflection-mode for a semi-infinite turbid geometry. The method is based on a generalized pulse spectrum technique that employs analytic expressions of the Laplace-transformed time-domain photon-diffusion model to construct a Born normalized inverse model, and a pair of real domain transform-factors to separate distributions of the fluorescent yield and lifetime. The methodology is validated with a specifically-developed fluorescent Monte-Carlo simulator or finite-element-based methods and its robustness to the background uncertainties is investigated.

Citation Download Citation

Huiyuan He, Limin Zhang, Feng Gao, Zheng Ma, Huijian Zhao, and Jingying Jiang "An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500M (12 February 2008); https://doi.org/10.1117/12.756377

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