Discrimination of shear mechanical and optical contrasts in tissue phantoms by use of opto-elastography

Khalid Daoudi; Albert-Claude Boccara; Emmanuel Bossy

doi:10.1117/12.763080

11 March 2008 Discrimination of shear mechanical and optical contrasts in tissue phantoms by use of opto-elastography

Khalid Daoudi, Albert-Claude Boccara, Emmanuel Bossy

Proceedings Volume 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 68560F (2008) https://doi.org/10.1117/12.763080
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Both mechanical and optical imaging of biological tissue can provide relevant contrasts in terms of biomedical tissue characterization. While ultrasound imaging can easily be performed at depth thanks to the weak scattering of ultrasound in soft tissue, the optical spatial resolution is limited for thick tissue by the strong scattering of light. In this paper, we present a technique involving the optical detection of a transient displacement caused by the acoustic radiation force created at cm depth by a focused intense short ultrasound burst (typically ~millisecond). This localized displacement disturbs the optical paths and allows localizing the information with a resolution dictated by the ultrasound spatial distribution. Using a high-speed camera, our objective was to detect and time-resolve displacements in the focal region and the associated propagation shear waves. Experiments were carried out in attenuating tissue-like media illuminated by a continuous laser source. In this work, we refined the optical detection scheme in order to work with low photons flux, based on two-phase heterodyne interferometry setup. We used tissue-mimicking phantoms with different optical and shear mechanical contrast. We demonstrate that it is possible to detect both types of contrast, and moreover to discriminate between these two types of contrast.

Citation Download Citation

Khalid Daoudi, Albert-Claude Boccara, and Emmanuel Bossy "Discrimination of shear mechanical and optical contrasts in tissue phantoms by use of opto-elastography", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560F (11 March 2008); https://doi.org/10.1117/12.763080

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissue optics

Cameras

Ultrasonography

Soft tissue optics

Bragg cells

Photons

Heterodyning

Show All Keywords

Keywords/Phrases

Search In:

Publication Years