Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography

Peter H. Tomlins; Yiwei Wang; Bufa Zhang; Matthew Tedaldi; Paul E. Tomlins

doi:10.1117/12.761772

6 February 2008 Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography

Peter H. Tomlins, Yiwei Wang, Bufa Zhang, Matthew Tedaldi, Paul E. Tomlins

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Proceedings Volume 6858, Optics in Tissue Engineering and Regenerative Medicine II; 685804 (2008) https://doi.org/10.1117/12.761772
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The flow of culture medium through a mechanically stimulated cell-seeded tissue scaffold is a factor influencing not only the transport of essential nutrients and waste product removal but also impacting on the degradation kinetics of the scaffold. Being able to map spatial and temporal changes in fluid flow behaviour is key to the development of improved bioreactors and tissue scaffold designs, especially for the new generation of multiple tissue reactors. In this paper we demonstrate the excellent metrological benefits of fast Doppler optical coherence tomography for time-lapse characterisation of tissue scaffolds placed in a dynamic flow environment.

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Peter H. Tomlins, Yiwei Wang, Bufa Zhang, Matthew Tedaldi, and Paul E. Tomlins "Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography", Proc. SPIE 6858, Optics in Tissue Engineering and Regenerative Medicine II, 685804 (6 February 2008); https://doi.org/10.1117/12.761772

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KEYWORDS

Optical coherence tomography

Tissues

Tissue optics

Fluid dynamics

Doppler tomography

CCD cameras

Doppler effect

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