Label-free detection of cytokines using optical microcavities

Andrea M. Armani; Scott E. Fraser

doi:10.1117/12.761002

21 February 2008 Label-free detection of cytokines using optical microcavities

Andrea M. Armani, Scott E. Fraser

Proceedings Volume 6862, Single Molecule Spectroscopy and Imaging; 68620C (2008) https://doi.org/10.1117/12.761002
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Ultra-high-Q microresonators have demonstrated sensitive and specific chemical and biological detection. The sensitivity is derived from the long photon lifetime inside the cavity and specificity is achieved through surface functionalization. Here, ultra-high-Q microcavities demonstrate label-free, single molecule detection of Interleukin-2 (IL-2) in fetal bovine serum (FBS). IL-2 is a cytokine released in response to immune system activation. The surface of the microtoroids was sensitized using anti-IL-2. The detection mechanism relies upon a thermo-optic mechanism to enhance resonant wavelength shifts induced through binding of a molecule.

Citation Download Citation

Andrea M. Armani and Scott E. Fraser "Label-free detection of cytokines using optical microcavities", Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620C (21 February 2008); https://doi.org/10.1117/12.761002

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