Laser-induced breakdown spectroscopy of whole blood and other liquid organic compounds

N. Melikechi; H. Ding; S. Rock; A. Marcano O.; D. Connolly

doi:10.1117/12.761901

14 March 2008 Laser-induced breakdown spectroscopy of whole blood and other liquid organic compounds

N. Melikechi, H. Ding, S. Rock, A. Marcano O., D. Connolly

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 68630O (2008) https://doi.org/10.1117/12.761901
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We report on laser-induced breakdown spectroscopy (LIBS) of whole blood and other organic fluids. LIBS spectra, in the region 200-970 nm, are measured by recording the radiation emitted by the samples following their ablation in a helium environment. We show that these spectra, although very complex, reveal the presence of elements such as nitrogen, hydrogen, oxygen and carbon and that of important metallic elements such as iron, magnesium, calcium, potassium, and sodium. We compare the measured LIBS spectra of whole blood to that of pure carbon and pure iron and find that in the 200-300 nm region. Nearly 90% of the peaks can be assigned to only these two elements. We also report on similar studies of methanol, ethanol, isopropanol and water solutions of protein molecules of interest to cancer research. We show that using simple numerical algorithms, it is possible to distinguish between complex organic compounds that have nearly the same chemical composition.

Citation Download Citation

N. Melikechi, H. Ding, S. Rock, A. Marcano O., and D. Connolly "Laser-induced breakdown spectroscopy of whole blood and other liquid organic compounds", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630O (14 March 2008); https://doi.org/10.1117/12.761901

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