Using skin impedance to improve prediction accuracy of continuous glucose monitoring system

Haixia Yu; Jin Liu; Ting Shi; Dachao Li; Zhenhui Du; Kexin Xu

doi:10.1117/12.762154

22 February 2008 Using skin impedance to improve prediction accuracy of continuous glucose monitoring system

Haixia Yu, Jin Liu, Ting Shi, Dachao Li, Zhenhui Du, Kexin Xu

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 68630S (2008) https://doi.org/10.1117/12.762154
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The continuous blood glucose monitoring system using interstitial fluid (ISF) extracted by ultrasound and vacuum is proposed in this paper. The skin impedance measurement is introduced into the system to monitor the skin permeability variation. Low-frequency ultrasound is applied on skin surface to enhance the skin permeability by disrupting the lipid bilayers of the stratum corneum (SC), and then ISF is extracted out of skin continuously by vacuum. The extracted ISF is diluted and the concentration of glucose in it is detected by a biosensor and used to predict the blood glucose concentration. The skin permeability is variable during the extraction, and its variation affects the prediction accuracy. The skin impedance is an excellent indicator of skin permeability in that the lipid bilayers of the SC, which offer electrical resistance to the skin, retard transdermal transport of molecules. So the skin impedance measured during the extraction is transformed to skin conductivity to estimate correlation coefficient between skin conductivity and permeability. Skin conductivity correlates well with skin permeability. The method and experiment system mentioned above may be significative for improving the prediction accuracy of continuous blood glucose monitoring system.

Citation Download Citation

Haixia Yu, Jin Liu, Ting Shi, Dachao Li, Zhenhui Du, and Kexin Xu "Using skin impedance to improve prediction accuracy of continuous glucose monitoring system", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630S (22 February 2008); https://doi.org/10.1117/12.762154

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available