Effects of sciatic nerve stimulation on the propagation of cortical spreading depression

Xiaoli Sun; Zhidong Yu; Shaoqun Zeng; Qingming Luo; Pengcheng Li

doi:10.1117/12.763372

14 March 2008 Effects of sciatic nerve stimulation on the propagation of cortical spreading depression

Xiaoli Sun, Zhidong Yu, Shaoqun Zeng, Qingming Luo, Pengcheng Li

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 68630U (2008) https://doi.org/10.1117/12.763372
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Cortical spreading depression (CSD) is an important pathological model of migraine and is related to other neural disorders, such as cerebral ischemia and epilepsy. It has been reported that brain stimulation is a quite effective way to treat neural diseases. However, direct stimulation could cause harm to brain. If peripheral nerve stimulation could have the same treatment, it would be essential to investigate the mechanisms of peripheral nerve and the study of sciatic nerve stimulation would have profound clinical meaning. In this paper, we used optical intrinsic signal imaging (OISI) and extracellular electrophysiologic recording techniques to study the effects of sciatic nerve stimulation on the propagation of CSD. We found that: (1) continuous sciatic nerve stimulation on rats caused a decrease in light intensity on the whole cortex, which meant an increase in cerebral blood volume(CBV); (2) the spreading velocity of CSD declined from 3.63± 0.272 mm/min to 3.06±0.260 mm/min during sciatic nerve stimulation, compared with that without sciatic nerve stimulation. In summary, data suggests that sciatic nerve stimulation elicits a response of cortex and causes a slowdown in the propagation of CSD.

Citation Download Citation

Xiaoli Sun, Zhidong Yu, Shaoqun Zeng, Qingming Luo, and Pengcheng Li "Effects of sciatic nerve stimulation on the propagation of cortical spreading depression", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630U (14 March 2008); https://doi.org/10.1117/12.763372

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