Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions

Hui-Hsin Lu; Chii-Wann Lin; Tzu-Chien Hsiao; Chih-Kung Lee; Su-Ming Hsu

doi:10.1117/12.762919

22 February 2008 Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions

Hui-Hsin Lu, Chii-Wann Lin, Tzu-Chien Hsiao, Chih-Kung Lee, Su-Ming Hsu

Proceedings Volume 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V; 68650D (2008) https://doi.org/10.1117/12.762919
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We employed atomic force microscopy (AFM) with bias control to fabricate oxided nanopatterns on silicon surface with feature size down to 50nm. The relationship of silicon dioxide nanopatterns against humidity was studied and then the optimal parameter was used to make oxide nanoarry for interaction of biotin and streptavidin. The scanning function of AFM was utilized to verify the different height of biomolecules. According to our experimental results, using nano biochip of silicon dioxide can decrease the monitoring scale to nanometer and can be the nano-platform for monitoring the behavior of biomolecular interaction. We anticipate mimicking the correlation of single molecular behavior and an array of biomolecular behavior to understand the coincidence of them.

Citation Download Citation

Hui-Hsin Lu, Chii-Wann Lin, Tzu-Chien Hsiao, Chih-Kung Lee, and Su-Ming Hsu "Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions", Proc. SPIE 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, 68650D (22 February 2008); https://doi.org/10.1117/12.762919

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