A microfluidic chemical/biological sensor based on dissolvable membrane incorporating gold nanoparticles and optical absorption

Chi-Wei Lo; Sudheer S. Sridharamurthy; Hongrui Jiang

doi:10.1117/12.768715

6 February 2008 A microfluidic chemical/biological sensor based on dissolvable membrane incorporating gold nanoparticles and optical absorption

Chi-Wei Lo, Sudheer S. Sridharamurthy, Hongrui Jiang

Author Affiliations +

Proceedings Volume 6885, MEMS/MOEMS Components and Their Applications V. Special Focus Topics: Transducers at the Micro-Nano Interface; 688507 (2008) https://doi.org/10.1117/12.768715
Event: MOEMS-MEMS 2008 Micro and Nanofabrication, 2008, San Jose, California, United States

Abstract

We present a microfluidic chemical/biological sensor based on dissolvable membranes incorporating gold nanoparticles. The presence of the target analyte in a fluidic sample being assayed dissolves the membrane, causing the change in its optical absorption. To enhance the contrast between the membrane and the fluidic sample, the membranes are chemically treated to exhibit strong absorption at certain wavelengths. Here, we use N,N'-cystaminebisacrylamide (CBA) cross-linked poly(acrylamide) (PAAm) membranes dissolved by a sample solution containing dithioerythritol (DTT) to demonstrate this approach. The dissolvable membrane incorporates gold nanoparticles to exhibit strong absorption at 572nm.

Citation Download Citation

Chi-Wei Lo, Sudheer S. Sridharamurthy, and Hongrui Jiang "A microfluidic chemical/biological sensor based on dissolvable membrane incorporating gold nanoparticles and optical absorption", Proc. SPIE 6885, MEMS/MOEMS Components and Their Applications V. Special Focus Topics: Transducers at the Micro-Nano Interface, 688507 (6 February 2008); https://doi.org/10.1117/12.768715

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