Analysis of photodynamic therapy applied to skin disorders by a topical photosensitizer

F. Fanjul-Vélez; O. G. Romanov; M. López-Escobar; M. A. Rodriguez-Colmenares; N. Ortega-Quijano; J. L. Arce-Diego

doi:10.1117/12.817983

18 November 2008 Analysis of photodynamic therapy applied to skin disorders by a topical photosensitizer

F. Fanjul-Vélez, O. G. Romanov, M. López-Escobar, M. A. Rodriguez-Colmenares, N. Ortega-Quijano, J. L. Arce-Diego

Proceedings Volume 7138, Photonics, Devices, and Systems IV; 71380J (2008) https://doi.org/10.1117/12.817983
Event: Photonics, Devices, and Systems IV, 2008, Prague, Czech Republic

Abstract

Optical treatment of pathological tissues comprises techniques like Low Intensity Laser Treatment (LILT) or Photodynamic Therapy (PDT). PDT consists on the inoculation of a photosensitizer in the tissue, which tends to be accumulated in cancerous cells, and on the posterior optical radiation of the area. The photosensitizer, that can be topical or systemic, is excited and cell necrosis is provoked. The collateral harmful effects of other destructive techniques, like radiotherapy or chemotherapy, are avoided with PDT. PDT can also be used as a complementary technique of conventional excisional surgical operations. The application of PDT to skin disorders is straightforward due to the fact that it is an external and accessible tissue. In this work, we analyze the application of PDT to several skin pathologies and the results obtained, by means of mainly the usage of Metvix^R as a topical photosensitizer and with an optical source in the range of 635 nm. The analysis includes a predictive model of the PDT process, based on an optical propagation equation and a photosensitizer degradation approach that provides an estimation of tissue destruction.

Citation Download Citation

F. Fanjul-Vélez, O. G. Romanov, M. López-Escobar, M. A. Rodriguez-Colmenares, N. Ortega-Quijano, and J. L. Arce-Diego "Analysis of photodynamic therapy applied to skin disorders by a topical photosensitizer", Proc. SPIE 7138, Photonics, Devices, and Systems IV, 71380J (18 November 2008); https://doi.org/10.1117/12.817983

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available