Bilateral responses of prefrontal and motor cortices to repetitive transcranial magnetic stimulation as measured by functional near infrared spectroscopy

Fenghua Tian; Frank Andrew Kozel; Sameer Dhamne; Shawn M. McClintock; Paul Croarkin; Kimberly Mapes; Mustafa M. Husain; Hanli Liu

doi:10.1117/12.809343

23 February 2009 Bilateral responses of prefrontal and motor cortices to repetitive transcranial magnetic stimulation as measured by functional near infrared spectroscopy

Fenghua Tian, Frank Andrew Kozel, Sameer Dhamne, Shawn M. McClintock, Paul Croarkin, Kimberly Mapes, Mustafa M. Husain, Hanli Liu

Author Affiliations +

Proceedings Volume 7161, Photonic Therapeutics and Diagnostics V; 71613C (2009) https://doi.org/10.1117/12.809343
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Simultaneously acquiring cortical functional Near Infrared Spectroscopy (fNIRS) during repeated Transcranial Magnetic Stimulation (rTMS) offers the possibility of directly investigating the effects of rTMS on brain regions without quantifiable behavioral changes. In this study, the left motor cortex and subsequently the left prefrontal cortex were stimulated at 1 Hz while fNIRS data was simultaneously acquired. Changes in hemodynamic signals were measured on both ipsilateral and contralateral sides. In each cortex, a significantly larger decrease in the concentration of oxygenated hemoglobin and a smaller increase in the concentration of deoxygenated hemoglobin during the stimulation periods were observed in both the motor and prefrontal cortices. The ipsilateral and contralateral changes showed high temporal consistency. Same experiment was repeated for each subject 2 or 3 days later. The hemodynamic responses associated with the stimulation showed good reproducibility in two sessions. To our knowledge, this is the first report of simultaneous fNIRS measurement of ipsilateral and contralateral changes of either the motor or prefrontal cortex during rTMS stimulation.

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Fenghua Tian, Frank Andrew Kozel, Sameer Dhamne, Shawn M. McClintock, Paul Croarkin, Kimberly Mapes, Mustafa M. Husain, and Hanli Liu "Bilateral responses of prefrontal and motor cortices to repetitive transcranial magnetic stimulation as measured by functional near infrared spectroscopy", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71613C (23 February 2009); https://doi.org/10.1117/12.809343

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KEYWORDS

Prefrontal cortex

Hemodynamics

Brain

Magnetism

Functional near infrared spectroscopy

Sensors

Data acquisition

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