Optical coherence tomography and Raman spectroscopy of the retina

Julia W. Evans; Robert J. Zawadzki; Rui Liu; James W. Chan; Stephen M. Lane; John S. Werner

doi:10.1117/12.807885

20 February 2009 Optical coherence tomography and Raman spectroscopy of the retina

Julia W. Evans, Robert J. Zawadzki, Rui Liu, James W. Chan, Stephen M. Lane, John S. Werner

Proceedings Volume 7171, Multimodal Biomedical Imaging IV; 71710O (2009) https://doi.org/10.1117/12.807885
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combining these imaging modalities. We present an ex vivo OCT microscope combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. The combined instrument will be used to investigate remaining technical challenges to combine these imaging modalities, such as the laser power levels needed to achieve a Raman signal above the noise level without damaging the sample.

Citation Download Citation

Julia W. Evans, Robert J. Zawadzki, Rui Liu, James W. Chan, Stephen M. Lane, and John S. Werner "Optical coherence tomography and Raman spectroscopy of the retina", Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710O (20 February 2009); https://doi.org/10.1117/12.807885

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KEYWORDS

Raman spectroscopy

Optical coherence tomography

Retina

In vivo imaging

Confocal microscopy

Raman scattering

Signal to noise ratio

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