Functional brain tomography using a time-gated ICCD camera

Antonio Pifferi; Qing Zhao; Lorenzo Spinelli; Andrea Bassi; Gianluca Valentini; Davide Contini; Rinaldo Cubeddu; Alessandro Torricelli

doi:10.1117/12.809690

23 February 2009 Functional brain tomography using a time-gated ICCD camera

Antonio Pifferi, Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Rinaldo Cubeddu, Alessandro Torricelli

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71741L (2009) https://doi.org/10.1117/12.809690
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The mean penetration depth of diffusely reflected photons is dependent on the arrival time t of photons, but not on the source-detector distance. Thus, all photons collected at the same t have the same depth sensitivity, and can be used for the reconstruction. Following this concept, we have implemented a system for 3D tomography using a single injection fiber and a time-gated ICCD camera. The feasibility of the novel approach to reconstruct a local perturbation was demonstrated both with simulations and phantom measurements. Finally, preliminary measurements were performed in vivo following a standard protocol of motor cortex activation.

Citation Download Citation

Antonio Pifferi, Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Rinaldo Cubeddu, and Alessandro Torricelli "Functional brain tomography using a time-gated ICCD camera", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741L (23 February 2009); https://doi.org/10.1117/12.809690

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