Determination of glucose concentration using Fourier domain optical coherence tomogram

Yasser H. El-Sharkawy

doi:10.1117/12.808415

23 February 2009 Determination of glucose concentration using Fourier domain optical coherence tomogram

Yasser H. El-Sharkawy

Proceedings Volume 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII; 71821L (2009) https://doi.org/10.1117/12.808415
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In order to enhance cell culture growth in biosensors such as those for glucose detection must be developed that are capable of monitoring cell culture processes continuously and accurate. Fourier domain optical coherence tomography (FD-OCT) is used to obtain cell images with nanometer level resolution by analyzing the interference pattern by the mixing of reference and objective light to determine glucose concentration in doped double distilled water and create a glucose signature spectrum in salt-sugar solution. We demonstrate ultrahigh-resolution optical coherence tomography (OCT) imaging of in vitro biological cells and an improved deflection angle measurements formal and back projection method is used to reconstruct the two-dimensional glucose concentration performs refractive index distribution. Slopes of OCT signals decreased substantially and almost linearly with the increase of glucose concentration from 2.5 to 15 mg/dl. Phantom studies demonstrated 1% accuracy of scattering- coefficient measurement. Our theoretical and experimental studies suggest that glucose concentration can potentially be measured non-invasively with high sensitivity and accuracy with OCT systems.

Citation Download Citation

Yasser H. El-Sharkawy "Determination of glucose concentration using Fourier domain optical coherence tomogram", Proc. SPIE 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 71821L (23 February 2009); https://doi.org/10.1117/12.808415

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