Path length resolved optical Doppler flowmetry

Babu Varghese; Vinayakrishnan Rajan; Ton G. Van Leeuwen; Wiendelt Steenbergen

doi:10.1117/12.807951

13 February 2009 Path length resolved optical Doppler flowmetry

Babu Varghese, Vinayakrishnan Rajan, Ton G. Van Leeuwen, Wiendelt Steenbergen

Proceedings Volume 7187, Biomedical Applications of Light Scattering III; 71870A (2009) https://doi.org/10.1117/12.807951
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The readings in laser Doppler perfusion monitoring are affected by the optical properties of the tissue in which the microvasculature is embedded, through their effect on the optical path lengths. Thus for a constant perfusion, the LDF output signal is affected by the variance in individual photon path lengths due to the changes in tissue optical properties and probe geometry. We will present efforts to render blood flow measurements independent of the tissue optical properties by using low coherence interferometry. We will give evidence of the improvement in quantification of our approach. In particular we show that low coherence interferometry can measure dynamic properties of particles in Brownian motion, independent of optical properties of the surrounding tissue matrices. Furthermore, demonstration is given of the applicability of the method in vivo.

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Babu Varghese, Vinayakrishnan Rajan, Ton G. Van Leeuwen, and Wiendelt Steenbergen "Path length resolved optical Doppler flowmetry", Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 71870A (13 February 2009); https://doi.org/10.1117/12.807951

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KEYWORDS

Doppler effect

Tissue optics

Absorption

Scattering

Optical properties

Blood

Phase modulation

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