Quantitative in vivo imaging of the lung using time-domain fluorescence measurements

Guobin Ma; Muriel Jean-Jacques; Lysanne Melanson-Drapeau; Mario Khayat

doi:10.1117/12.809448

16 February 2009 Quantitative in vivo imaging of the lung using time-domain fluorescence measurements

Guobin Ma, Muriel Jean-Jacques, Lysanne Melanson-Drapeau, Mario Khayat

Proceedings Volume 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV; 71910C (2009) https://doi.org/10.1117/12.809448
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In this paper, nebulized or intravenous cetuximab (also known as Erbitux) labeled with NIR dyes is administered in the lungs of the mouse and imaged using a time-domain fluorescence imaging system (Optix^(R)). Time resolved measurements provide lifetime of the fluorescent probes. In addition, through time-of-flight information contained in the data, one can also assess probe localization and concentration distribution quantitatively. Results shown include suppression of tissue autofluorescence by lifetime gating and recovery of targeted and non-targeted distributions of cetuximab labeled with the NIR fluorophores.

Citation Download Citation

Guobin Ma, Muriel Jean-Jacques, Lysanne Melanson-Drapeau, and Mario Khayat "Quantitative in vivo imaging of the lung using time-domain fluorescence measurements", Proc. SPIE 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV, 71910C (16 February 2009); https://doi.org/10.1117/12.809448

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KEYWORDS

Luminescence

Lung

In vivo imaging

Near infrared

Imaging systems

Image restoration

Lung cancer

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