Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography

Thomas Jetzfellner; Daniel Razansky; Amir Rosenthal; Ralf Schulz; K.-H. Englmeier; Vasilis Ntziachristos

doi:10.1117/12.811014

13 March 2009 Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography

Thomas Jetzfellner, Daniel Razansky, Amir Rosenthal, Ralf Schulz, K.-H. Englmeier, Vasilis Ntziachristos

Author Affiliations +

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 725812 (2009) https://doi.org/10.1117/12.811014
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

We describe an improved optoacoustic tomography method, that utilizes a diffusion-based photon propagation model in order to obtain quantified reconstruction of targets embedded deep in heterogeneous scattering and absorbing tissue. For the correction we utilize an iterative finite-element solution of the light diffusion equation to build a photon propagation model. We demonstrate image improvements achieved by this method by using tissue-mimicking phantom measurements. The particular strength of the method is its ability to achieve quantified reconstructions in non-uniform illumination configurations resembling whole-body small animal imaging scenarios.

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Thomas Jetzfellner, Daniel Razansky, Amir Rosenthal, Ralf Schulz, K.-H. Englmeier, and Vasilis Ntziachristos "Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725812 (13 March 2009); https://doi.org/10.1117/12.811014

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