Comparison of surface functionalization processes for optical fibre biosensing applications

Alexandre François; Heike Ebendorff-Heidepriem; Tanya M. Monro

doi:10.1117/12.835283

5 October 2009 Comparison of surface functionalization processes for optical fibre biosensing applications

Alexandre François, Heike Ebendorff-Heidepriem, Tanya M. Monro

Proceedings Volume 7503, 20th International Conference on Optical Fibre Sensors; 75030U (2009) https://doi.org/10.1117/12.835283
Event: 20th International Conference on Optical Fibre Sensors, 2009, Edinburgh, United Kingdom

Abstract

Optical fibres are a platform of interest for biosensing due to their low cost, high robustness and long interaction length with their surroundings. However, the sensitivity of these techniques lags behind chemiluminescence and other techniques. Here we explore opportunities for improving the sensitivity of fibre-based biosensors by investigating the process by which biomolecules are immobilized onto the glass. Two immobilization technologies are compared: the well-known silane technology and the emerging polyelectrolyte method. This was done using a specific interaction model based on biotin-streptavidin. The number of specific binding sites as well as the induced losses within a microstructured fibre has been characterized.

Citation Download Citation

Alexandre François, Heike Ebendorff-Heidepriem, and Tanya M. Monro "Comparison of surface functionalization processes for optical fibre biosensing applications", Proc. SPIE 7503, 20th International Conference on Optical Fibre Sensors, 75030U (5 October 2009); https://doi.org/10.1117/12.835283

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available