Collagen remodeling in photo-thermal damaged skin with optical coherence tomography and multiphoton microscopy

Shu-lian Wu; Hui Li; Xiao-man Zhang; Lili Yu

doi:10.1117/12.841617

28 October 2009 Collagen remodeling in photo-thermal damaged skin with optical coherence tomography and multiphoton microscopy

Shu-lian Wu, Hui Li, Xiao-man Zhang, Lili Yu

Author Affiliations +

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75190B (2009) https://doi.org/10.1117/12.841617
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

Cutaneous photo-thermal damage is the common damages in clinical medicine; it is a complex and dynamic process that follows an orderly sequence of events. The sequence can be roughly divided into three distinct, yet sequentially overlapping phases-inflammation, granulation tissue formation, and tissue remodeling. Characteristic structural changes associated with each phase could provide a basis for photo-thermal damage assessment with imaging technologies. Monitoring the skin tissue response during the skin after irradiated by laser and tracing the process of skin remodeling would help to understand the mechanism of photo-thermal. Optical coherence tomography (OCT) and multiphoton microscopy (MPM) imaging were used to observe the process of the collagen remodeling in mouse dermis photo-thermal injured which after irradiated by intense pulsed light source (IPLs) in this paper. Our finding showed that the OCT and MPM techniques can image the process of collagen remodeling in mouse dermis.

Citation Download Citation

Shu-lian Wu, Hui Li, Xiao-man Zhang, and Lili Yu "Collagen remodeling in photo-thermal damaged skin with optical coherence tomography and multiphoton microscopy", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190B (28 October 2009); https://doi.org/10.1117/12.841617

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KEYWORDS

Optical coherence tomography

Collagen

Skin

Second-harmonic generation

Multiphoton microscopy

Tissue optics

Tissues

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