Differentiating normal and cancerous stroma by nonlinear spectral imaging

Shuangmu Zhuo; Jianxin Chen; Shusen Xie; Liqin Zheng; Xiaoqin Zhu; Xingshan Jiang

doi:10.1117/12.841971

28 October 2009 Differentiating normal and cancerous stroma by nonlinear spectral imaging

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Liqin Zheng, Xiaoqin Zhu, Xingshan Jiang

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75190F (2009) https://doi.org/10.1117/12.841971
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

In this work, we demonstrate the use of the nonlinear spectral imaging technique in differentiating normal and cancerous stroma. It was found that nonlinear spectral images from normal and neoplastic stroma exhibit different organization features. Combining the image-guided spectral analysis function and the extracting channels function, some information on the biomorphology and biochemistry of tissue can be acquired, including alteration in proportions of matrix molecules, collagen-related changes, elastin-related changes. These results give insight into the stromal changes associated with cancer progression and provide substantial potential to be applied in vivo the clinical diagnosis of epithelial precancers and cancers.

Citation Download Citation

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Liqin Zheng, Xiaoqin Zhu, and Xingshan Jiang "Differentiating normal and cancerous stroma by nonlinear spectral imaging", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190F (28 October 2009); https://doi.org/10.1117/12.841971

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KEYWORDS

Cancer

Imaging spectroscopy

Collagen

Tissues

Biochemistry

Biopsy

Image analysis

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