In vivo XRF measurement of lead in bone: theory and important progress

Weisong Yi; Xianqing Luo

doi:10.1117/12.839856

28 October 2009 In vivo XRF measurement of lead in bone: theory and important progress

Weisong Yi, Xianqing Luo

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75190Q (2009) https://doi.org/10.1117/12.839856
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

Lead is a leading environmental toxicant and Lead exposure has effects on many systems. Bone lead measured in vivo, has been shown to reflect cumulative lead exposure. Objective: To introduce and study in vivo XRF Measurements of Lead in Bone. Methods: Important progress and technology were summarized and introduced. Results: In vivo XRF is a safe and effective tool, which has enabled skeletal lead concentration measurement. X-ray spectrometry in vivo has contributed to the understanding of long-term human lead metabolism in ways that would not otherwise have happened. Conclusion: Efforts to introduce further improvements to the XRF technique are ongoing in order to lower its measurement uncertainty and enhance reproducibility. This may become especially important as the method becomes more widely used in the study of non-occupationally exposed populations, whose bone lead concentrations are generally quite low and thus comparable with the MDL of the standard XRF technique.

Citation Download Citation

Weisong Yi and Xianqing Luo "In vivo XRF measurement of lead in bone: theory and important progress", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190Q (28 October 2009); https://doi.org/10.1117/12.839856

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KEYWORDS

Lead

Bone

In vivo imaging

X-rays

Monte Carlo methods

Spectroscopy

Absorption

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