Quantified characterization of dermal collagen structure in human cutaneous scars from second harmonic generation imaging

Xiaoqin Zhu; Youting Chen; Shuangmu Zhuo; Biying Yu; Liqin Zheng; Kecheng Lu; Jianxin Chen

doi:10.1117/12.843456

28 October 2009 Quantified characterization of dermal collagen structure in human cutaneous scars from second harmonic generation imaging

Xiaoqin Zhu, Youting Chen, Shuangmu Zhuo, Biying Yu, Liqin Zheng, Kecheng Lu, Jianxin Chen

Author Affiliations +

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75191B (2009) https://doi.org/10.1117/12.843456
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

In this paper, high resolution images of collagens based on second harmonic generation (SHG) were obtained in the dermis of different scar tissues and surrounding considered uninjured skins, demonstrating differences in their microstructures. In order to quantitatively analyze their structural features, Fourier analysis was applied for the SHG images to compare the alteration in collagen orientation of different scars. Moreover, depth dependant decay of SHG signals was also analyzed to provide more credible information. Our results show that the different types of scar tissues can be successfully distinguished with the two combined methods, which will help to determine the most appropriate clinical treatment strategy.

Citation Download Citation

Xiaoqin Zhu, Youting Chen, Shuangmu Zhuo, Biying Yu, Liqin Zheng, Kecheng Lu, and Jianxin Chen "Quantified characterization of dermal collagen structure in human cutaneous scars from second harmonic generation imaging", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75191B (28 October 2009); https://doi.org/10.1117/12.843456

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