Mechanical compression for biotissue image enhancement in optical coherence tomography

P. D. Agrba; M. Yu. Kirillin; A. I. Abelevich; V. A. Kamensky

doi:10.1117/12.853436

11 February 2010 Mechanical compression for biotissue image enhancement in optical coherence tomography

P. D. Agrba, M. Yu. Kirillin, A. I. Abelevich, V. A. Kamensky

Proceedings Volume 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics; 754703 (2010) https://doi.org/10.1117/12.853436
Event: Saratov Fall Meeting 2009, 2009, Saratov, Russian Federation

Abstract

The paper discusses application of mechanical compression for contrasting structural components of biotissues with different mechanical properties in optical coherence tomography (OCT) images. Ex vivo study on human rectum samples and in vivo study on human thin skin samples are performed. It is shown that for ex vivo sample the contrast between epithelial and stroma layers increases with increase in applied pressure. For in vivo sample it is shown that at weak constant applied pressure the contrast between epidermal and dermal layer increases exhibiting maximum after 2-3 minutes since pressure application. Monte Carlo simulations of OCT images of human rectum sample at different compression levels is performed in order to confirm the origin of contrast. The results of simulations qualitatively agree with experimental data.

Citation Download Citation

P. D. Agrba, M. Yu. Kirillin, A. I. Abelevich, and V. A. Kamensky "Mechanical compression for biotissue image enhancement in optical coherence tomography", Proc. SPIE 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics, 754703 (11 February 2010); https://doi.org/10.1117/12.853436

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