Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice

Lihua Bai; Jianxia Guo; Dana M. Clausen; Julie L. Eiseman

doi:10.1117/12.842357

2 March 2010 Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice

Lihua Bai, Jianxia Guo, Dana M. Clausen, Julie L. Eiseman

Author Affiliations +

Proceedings Volume 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX; 75510T (2010) https://doi.org/10.1117/12.842357
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Objective: In in vitro photodynamic therapy, the LD50 of Pc 181 has been reported to be 7 to 8 times less than that of silicon phthalocyanine 4 (Pc 4). The Optical Pharmacokinetic System (OPS) can measure photosensitizer concentrations in accessible tissues non-invasively. We used OPS to evaluate the tumor pharmacokinetics of Pc 181 and Pc 4 and the tissue drug distribution in SCID mice bearing either human breast cancer MDA-MB-231 or human head and neck squamous cell carcinoma SCC-15 xenografts. Methods: Following iv administration of 2.5 mg/kg Pc 181 or 2 mg/kg Pc 4 to SCID mice, OPS measurements were taken on tumor and normal tissues between 5 and 4320 min in vivo or in situ. Results: Large variations in tumor Pc 181 concentrations were observed among mice. In MDA-MB-231 tumors, the Pc 181 concentration peaked at 240 min, and was retained in the tumor. Tumor Pc 181 concentrations were much less than the tumor Pc 4 concentrations at an equimolar dose. Pc 181 concentrations were the highest in liver, followed by spleen, and kidney. In mice bearing SCC-15 xenografts, skin and underlying tissue Pc 181 concentrations were higher than tumor concentrations at all time points examined. Conclusions: This first Pc 181 pharmacokinetics study described a tissue Pc 181 distribution similar to that of Pc 4. However, tumor Pc 181 concentrations were lower than those of Pc 4 at equimolar doses.

Citation Download Citation

Lihua Bai, Jianxia Guo, Dana M. Clausen, and Julie L. Eiseman "Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510T (2 March 2010); https://doi.org/10.1117/12.842357

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