Diffuse reflectance spectroscopy of pre- and post-treated oral submucous fibrosis: an in vivo study

S. Sivabalan; C. Ponranjini Vedeswari; S. Jayachandran; D. Koteeswaran; C. Pravda; P. Aruna; S. Ganesan

doi:10.1117/12.843090

11 February 2010 Diffuse reflectance spectroscopy of pre- and post-treated oral submucous fibrosis: an in vivo study

S. Sivabalan, C. Ponranjini Vedeswari, S. Jayachandran, D. Koteeswaran, C. Pravda, P. Aruna, S. Ganesan

Proceedings Volume 7561, Optical Biopsy VII; 75610T (2010) https://doi.org/10.1117/12.843090
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Oral submucous fibrosis (OSF) is a high risk precancerous condition characterized by changes in the connective tissue fibers of the lamina propria and deeper parts leading to stiffness of the mucosa and restricted mouth opening, fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oro- and hypo-pharynx and the upper two-thirds of the oesophagus. Optical reflectance measurements have been used to extract diagnostic information from a variety of tissue types, in vivo. We apply diffuse reflectance spectroscopy to quantitatively monitor tumour response to chemotherapy. Twenty patients with submucous fibrosis were diagnosed with diffuse reflectance spectroscopy and treated with the chemotherapy drug, Dexamethasone sodium phosphate and Hyaluronidase injection for seven weeks and after the treatment they were again subjected to the diffuse reflectance spectroscopy. The major observed spectral alterations on pre and post treated submucous fibrosis is an increase in the diffuse reflectance from 450 to 600 nm. Normal mucosa has showed higher reflectance when compared to the pre and post-treated cases. The spectral changes were quantified and correlated to conventional diagnostic results viz., maximum mouth opening, tongue protrusion and burning sensation. The results of this study suggest that the diffuse reflectance spectroscopy may also be considered as complementary optical techniques to monitor oral tissue transformation.

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S. Sivabalan, C. Ponranjini Vedeswari, S. Jayachandran, D. Koteeswaran, C. Pravda, P. Aruna, and S. Ganesan "Diffuse reflectance spectroscopy of pre- and post-treated oral submucous fibrosis: an in vivo study", Proc. SPIE 7561, Optical Biopsy VII, 75610T (11 February 2010); https://doi.org/10.1117/12.843090

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KEYWORDS

Diffuse reflectance spectroscopy

Tissue optics

In vivo imaging

Mouth

Reflectivity

Diagnostics

Cancer

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