Fat tissue staining and photodynamic/photothermal effects

Valery V. Tuchin; Gregory B. Altshuler; Irina Yu. Yanina; Vyacheslav I. Kochubey; Georgy V. Simonenko

doi:10.1117/12.849346

25 February 2010 Fat tissue staining and photodynamic/photothermal effects

Valery V. Tuchin, Gregory B. Altshuler, Irina Yu. Yanina, Vyacheslav I. Kochubey, Georgy V. Simonenko

Proceedings Volume 7563, Dynamics and Fluctuations in Biomedical Photonics VII; 75630V (2010) https://doi.org/10.1117/12.849346
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Cellulite is considered as a disease of the subcutaneous fat layer that appears mostly in women and consists of changes in fat cell accumulation together with disturbed lymphatic drainage, affecting the external appearance of the skin. The photodynamic and selective photothermal treatments may provide reduction the volume of regional or sitespecific accumulations of subcutaneous adipose tissue on the cellular level. We hypothesize that light irradiation of stained fat tissue at selected temperature leads to fat cell lypolytic activity (the enhancement of lipolysis of cell triglycerides due to expression of lipase activity and cell release of free fat acids (FFAs) due to temporal cell membrane porosity), and cell killing due to apoptosis caused by the induced fat cell stress and/or limited cell necrosis.

Citation Download Citation

Valery V. Tuchin, Gregory B. Altshuler, Irina Yu. Yanina, Vyacheslav I. Kochubey, and Georgy V. Simonenko "Fat tissue staining and photodynamic/photothermal effects", Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630V (25 February 2010); https://doi.org/10.1117/12.849346

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