Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model

Song Hu; Sunday Oladipupo; Junjie Yao; Andrea C. Santeford; Konstantin Maslov; Joanna Kovalski; Jeffrey M. Arbeit; Lihong V. Wang

doi:10.1117/12.841177

23 February 2010 Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model

Song Hu, Sunday Oladipupo, Junjie Yao, Andrea C. Santeford, Konstantin Maslov, Joanna Kovalski, Jeffrey M. Arbeit, Lihong V. Wang

Author Affiliations +

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 756406 (2010) https://doi.org/10.1117/12.841177
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.

Citation Download Citation

Song Hu, Sunday Oladipupo, Junjie Yao, Andrea C. Santeford, Konstantin Maslov, Joanna Kovalski, Jeffrey M. Arbeit, and Lihong V. Wang "Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (23 February 2010); https://doi.org/10.1117/12.841177

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available